Kinetic resolution of racemic alcohols with chiral carboxylic acids and dicyclohexylcarbodiimide

Article abstract of DOI:10.1016/S0957-4166(00)82271-5

The DCC-esterification method has been used to kinetically resolve racemic mixtures of alcohols. With simple chiral carboxylic acids, such as O-aryl lactic acids, in the presence of various basic catalysts, mixtures of the enantiomerically enriched alcohols (e.e. < 50%) and the corresponding esters (d.e. < 70%) have been obtained.