Synthesis, Hydrolysis Rates, Supercomputer Modeling, and Antibacterial Activity of Bicyclic Tetrahydropyridazinones

DOI: 10.1021/jm00109a030

Source and publish data:

Journal of Medicinal Chemistry p. 1732 - 1739 (1991)

Update date:2022-08-04

Topics:

Authors:

Jungheim, Louis N.

Boyd, Donald B.

Indelicato, Joseph M.

Pasini, Carol E.

Preston, David A,.

Alborn, William E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00109a030

Bicyclic tetrahydropyridazinones, such as 13, where X are strongly electron-withdrawing groups, were synthesized to investigate their antibacterial activity.These δ-lactams are homologues of bicyclic pyrazolidinones 15, which were the first non-β-lactam-c

Full text of DOI:10.1021/jm00109a030

Products guided by the article

Product name:7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5,6,7,8-tetrahydro-3H-pyrazolo[1,2-a]pyridazine-1,2-dicarboxylic acid diallyl ester

Cas No:133627-80-2

R&D Labs maybe for 133627-80-2

Dayang Chem (Hangzhou) Co.,Ltd.

website:http://www.dycnchem.com

Contact:+86-571-88938639

Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Hebei Kangtai Pharmaceutical Co.,Ltd

Contact:+86-0317-3512963

Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Jiangxi Hito Chemical Co., Ltd.

Contact:+86-792-3170318

Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
Zibo Linzi Darong Fine Chemical Co., Ltd(expird)

Contact:86-532-67773200; 15689126900

Address:Qidu town,Linzi district,Zibo city,Shandong province,China

Relevant to this article

Access to phosphorus-rich zirconium complexes

Doi:10.1002/anie.201103634
(2011)
Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities

Doi:10.1016/j.bmcl.2011.08.035
(2011)
Iron-Catalyzed Cross-Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow

Doi:10.1002/chem.201904480
(2019)
Chromium complexes with acenaphthene imine derivative ligands synthesis and catalysis on diene polymerization

Doi:10.1021/om200733e
(2011)
Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells

Doi:10.1016/j.bmc.2013.08.057
(2013)
Synthesis and structural characterization of pincer type bicyclic diacyloxy- and diazaselenuranes

Doi:10.1039/c1dt10862j
(2011)

Article Doi