Synthesis, Hydrolysis Rates, Supercomputer Modeling, and Antibacterial Activity of Bicyclic Tetrahydropyridazinones

Article abstract of DOI:10.1021/jm00109a030

Bicyclic tetrahydropyridazinones, such as 13, where X are strongly electron-withdrawing groups, were synthesized to investigate their antibacterial activity.These δ-lactams are homologues of bicyclic pyrazolidinones 15, which were the first non-β-lactam-c