Synthesis, Hydrolysis Rates, Supercomputer Modeling, and Antibacterial Activity of Bicyclic Tetrahydropyridazinones

DOI: 10.1021/jm00109a030

Source and publish data:

Journal of Medicinal Chemistry p. 1732 - 1739 (1991)

Update date:2022-08-04

Topics:

Authors:

Jungheim, Louis N.

Boyd, Donald B.

Indelicato, Joseph M.

Pasini, Carol E.

Preston, David A,.

Alborn, William E.

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Article abstract of DOI:10.1021/jm00109a030

Bicyclic tetrahydropyridazinones, such as 13, where X are strongly electron-withdrawing groups, were synthesized to investigate their antibacterial activity.These δ-lactams are homologues of bicyclic pyrazolidinones 15, which were the first non-β-lactam-c

Full text of DOI:10.1021/jm00109a030

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