Tetrahedron p. 4425 - 4432 (1984)
Update date:2022-08-04
Topics:
Khmel'nitski, Yu. L.
Dien, Fam Khyu
Semenov, A. N.
Martinek, Karel
Optimal conditions were found for enzymatic synthesis of the dipeptide, N-acetyl-L-tryptophanyl-L-leucine amide in the biphasic system water - ethyl acetate.The synthesis was carried out using both free and immobilized α-chymotrypsin.Optimization was performed by such parameters as the "organic phase/aqueous phase" volume ratio, the pH of aqueous phase, and the concentration of starting reactants.Under most favourable conditions the dipeptide was synthesized on the preparative scale in ca. 100percent yield.As a result of immobilization (adsorption on the Sorsilen terephtalate support) the enzyme practically did not inactivate and may be used repeatedly.
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