Tetrahedron p. 4425 - 4432 (1984)
Update date:2022-08-04
Topics:
Khmel'nitski, Yu. L.
Dien, Fam Khyu
Semenov, A. N.
Martinek, Karel
Optimal conditions were found for enzymatic synthesis of the dipeptide, N-acetyl-L-tryptophanyl-L-leucine amide in the biphasic system water - ethyl acetate.The synthesis was carried out using both free and immobilized α-chymotrypsin.Optimization was performed by such parameters as the "organic phase/aqueous phase" volume ratio, the pH of aqueous phase, and the concentration of starting reactants.Under most favourable conditions the dipeptide was synthesized on the preparative scale in ca. 100percent yield.As a result of immobilization (adsorption on the Sorsilen terephtalate support) the enzyme practically did not inactivate and may be used repeatedly.
View MoreZhejiang PRIMAR Import & Export Trade Co., Ltd.
Contact:86-570-3630818
Address:No.1Puzhuyuan,Quhua,Zhejiang Province,China324004
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong,Yuandong Road Fengxian District, Shanghai ,China
Changzhou Hopschain Chemical Co.,Ltd
website:http://www.hopschem.cn/products.html
Contact:86-519-85528066
Address:Room 710, Unit A, Xingbei Development Mansion, Tongjiang Road, Changzhou City,213000, China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Wuhan Jadechem International Trade Co.,Ltd.
website:http://www.jadechem-intl.com
Contact:+86-27-83527060
Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
Doi:10.1002/chem.201904480
(2019)Doi:10.1021/om200733e
(2011)Doi:10.1016/j.bmc.2013.08.057
(2013)Doi:10.1039/c1dt10862j
(2011)Doi:10.1021/ol202492x
(2011)Doi:10.1080/00958972.2011.616197
(2011)