Zinc-copper(I) chloride or -silver acetate promoted coupling reaction of 2-[(Trimethylsilyl)methyl]-3-chloro-3,3-difluoropropene with carbonyl compounds. Highly efficient access to 2,2-difluoro homoallyl alcohols

DOI: 10.1016/S0040-4039(00)74490-X

Source and publish data:

Tetrahedron Letters p. 1069 - 1072 (1991)

Update date:2022-08-03

Topics:

Authors:

Ishihara, Takashi

Miwatashi, Seiji

Kuroboshi, Manabu

Utimoto, Kiitiro

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Article abstract of DOI:10.1016/S0040-4039(00)74490-X

2-[(Trimethylsilyl)methyl]-3-chloro-3,3-difluoropropene, readily prepared in two steps from methyl chlorodifluoroacetate and (trimethylsilyl)methylmagnesium chloride, is reduced to couple regioselectivity with a variety of carbonyl compounds in the presen

Full text of DOI:10.1016/S0040-4039(00)74490-X

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