General approach to halogenated tetrahydrofuran natural products from red algae of the genus Laurencia. Total synthesis of (±)-trans-kumausyne and demonstration of an asymmetric synthesis strategy

Article abstract of DOI:10.1021/ja00014a032

A general strategy for the synthesis of C₁₅ halogenated tetrahydrofuranoid lipids from red algae of the genus Laurencia has been developed. The central step is the convenient formation of hydrobenzofuranone (±)-5 on a large scale, and with comp