Journal of Asian Natural Products Research p. 985 - 992 (2013)
Update date:2022-09-26
Topics:
Liu, Jing
Cao, Bo
Gao, Ying
Bai, Mei
Mei, Xin
Chen, Hong
Jiang, Yun-Gen
Huang, Da-Jiang
In order to find novel synthetic compounds with superior antitumor activity and overcome multidrug resistance, a series of novel 4β-N-substituted podophyllotoxin derivatives were synthesized under mild conditions with satisfactory yield. Nine novel podophyllotoxin derivatives were synthesized by linking 4β-amino-podophyllotoxin with aldehydes via the formation of a Schiff's base, and imines were reducted to secondary amines. These novel derivatives have been evaluated for cytotoxicity against human cancer cell lines Hela, K562, and K562/AO2. The results indicated that these compounds possess superior bioactivity (IC50 values were found at the range of 10 -6-10-8 mol/l) and weak multidrug resistance.
View MoreDalian Synco Chemical Co., Ltd.
Contact:+86-411-83635150
Address:Rm 1004, 24, Tangshan Street, Dalian
Hebei Lead Bio-Chemicals Co., Ltd.
website:http://www.ldbiochem.com
Contact:+86-311-87826503
Address:481, Heping West Road, Shijiazhuang,China
Contact:+86-25-52346955
Address:199,JIANYE ROAD,NANJING,CHINA
Changzhou Baolong Chemical Industrial Co.,Ltd
website:http://www.czbaolong.com
Contact:0519-85720726 0519-85720721 13951213302
Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
Hangzhou Pharma & Chem Co.,Ltd.
Contact:+86-571-87040515
Address:No,139Qingchun Rd
Doi:10.1002/chem.201102206
(2011)Doi:10.1021/ic201911f
(2011)Doi:10.1016/0040-4039(91)80359-E
(1991)Doi:10.1039/c1ob06138k
(2011)Doi:10.1021/ja00047a013
(1992)Doi:10.1055/s-1980-28942
(1980)