Naphtho and benzo analogues of the κ opioid agonist trans-(±)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide

Article abstract of DOI:10.1021/jm00110a021

Further elaboration on the structure-activity relationships in our U-50,488 series has revealed that benzologation of this cyclohexane-1,2-diamine derivative provides compounds which either maintain the interaction with the κ receptor (e.g. compounds 3a a