Naphtho and benzo analogues of the κ opioid agonist trans-(±)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide

DOI: 10.1021/jm00110a021

Source and publish data:

Journal of Medicinal Chemistry p. 1891 - 1896 (1991)

Update date:2022-08-03

Topics:

Authors:

Freeman Freeman

Michalson

D'Andrea

Baczynskyj

VonVoigtlander

Lahti Lahti

Smith Smith

Lawson Lawson

Scahill Scahill

Mizsak Mizsak

Szmuszkovicz

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Article abstract of DOI:10.1021/jm00110a021

Further elaboration on the structure-activity relationships in our U-50,488 series has revealed that benzologation of this cyclohexane-1,2-diamine derivative provides compounds which either maintain the interaction with the κ receptor (e.g. compounds 3a a

Full text of DOI:10.1021/jm00110a021

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Product name:trans-2-pyrrolidinyl-3-(N-methyl-3',4'-dichlorophenylacetamido)-1,2,3,4-tetrahydronaphthalene

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