Naphthosultam Derivatives: A New Class of Potent and Selective 5-HT2 Antagonists

DOI: 10.1021/jm00112a025

Source and publish data:

Journal of Medicinal Chemistry p. 2477 - 2483 (1991)

Update date:2022-07-29

Topics: Selectivity Potency Research and Development Pharmacological Activity Therapeutic Potential

Authors:

Malleron, Jean-Luc

Comte, Marie-Therese

Gueremy, Claude

Peyronel, Jean Francois

Truchon, Alain

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00112a025

A series of 2-(aminoalkyl)naphth<1,8-cd>isothiazole 1,1-dioxides was synthesized and examined in various receptor binding tests.Most compounds demonstrated high affinity for the 5-HT₂ receptor with moderate to high selectivity.A member of this

Full text of DOI:10.1021/jm00112a025

Products guided by the article

Product name:N-<3-(4-phenyl-1,2,3,6-tetrahydropyridyl)propyl>-N-(1-naphthyl)methanesulfonamide

Cas No:134133-52-1

R&D Labs maybe for 134133-52-1

Taizhou Crene Biotechnology co.ltd

Contact:86-576-88813233 88205808

Address:Economic Developed Zone of Taizhou Zhejiang China
Tianjin Chemsyntech Chemical Co., Ltd

Contact:+86-22-60872258

Address:Haitai green industry base in Tianjin, K1,5-601
Purestar Chem Enterprise Co.,Ltd

website:http://www.purestarchem.com

Contact:05722157374

Address:no235.huanchengdong Rd
Weifang Ocean Trading Co., Ltd.

Contact:+86-536-2081155

Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China
Jinan Jianfeng Chemical Co., Ltd

Contact:0086-531-88110457

Address:sales01(-a-t-)pharmachemm{dot}c+o+m

Relevant to this article

Design and synthesis of novel (Z)-5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)-3-((1-substituted phenyl-1H-1,2,3-triazol-4-yl)methyl)thiazolidine-2,4-diones: a potential cytotoxic scaffolds and their molecular modeling studies

Doi:10.1007/s11030-020-10093-3
(2021)
Phosphoryl-transfer reactions of phosphodiesters: Characterization of transition states by heavy-atom isotope effects

Doi:10.1021/ja00015a043
(1991)
Exploiting the acylating nature of the imide-ugi intermediate: A straightforward synthesis of tetrahydro-1,4-benzodiazepin-2-ones

Doi:10.1021/jo2015054
(2011)
Cytotoxicity and gene expression profiles of novel synthesized steroid derivatives as chemotherapeutic anti-breast cancer agents

Doi:10.1016/j.bmc.2011.09.033
(2011)
Polycyclic N-hetero compounds; XXXIX: A facile synthesis of 1,2,4,5-Tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines

Doi:10.1055/s-1991-26450
(1991)
Citalopram hydrobromide: Degradation product characterization and a validated stability-indicating LC-UV method

Doi:10.1590/S0103-50532011000500005
(2011)

Article Doi