Naphthosultam Derivatives: A New Class of Potent and Selective 5-HT2 Antagonists

DOI: 10.1021/jm00112a025

Source and publish data:

Journal of Medicinal Chemistry p. 2477 - 2483 (1991)

Update date:2022-07-29

Topics: Selectivity Potency Research and Development Pharmacological Activity Therapeutic Potential

Authors:

Malleron, Jean-Luc

Comte, Marie-Therese

Gueremy, Claude

Peyronel, Jean Francois

Truchon, Alain

et al. et al.

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Article abstract of DOI:10.1021/jm00112a025

A series of 2-(aminoalkyl)naphth<1,8-cd>isothiazole 1,1-dioxides was synthesized and examined in various receptor binding tests.Most compounds demonstrated high affinity for the 5-HT₂ receptor with moderate to high selectivity.A member of this

Full text of DOI:10.1021/jm00112a025

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