A novel route to N-alkylated derivatives of aziridine-2-carboxylic acid. An alternative synthesis of (S,S)-Bz-Azy-Val-OMe

Article abstract of DOI:10.1080/00397919108020818

A novel method for N-alkylation of azyridine-2-carboxylic acid derivative with benzyl chloride under phase-transfer conditions or using KF/Al₂O₃ as a base was developed. The latter variant of this method was applied to carry out the key step of the alternative synthesis of the dipeptide (S,S)-Bz-Azy-Val-Ome.

Full text of DOI:10.1080/00397919108020818

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Synthetic Communications: An
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Organic Chemistry
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A Novel Route to N-Alkylated
Derivatives of Aziridine-2-
Carboxylic Acid. an Alternative
Synthesis of (S,S)-Bz-Azy-Val-
OMe
F. Polyak a , T. Dorofeeva a , R. Sturkovich a & Yu.
Goldberg a
a Institute of Organic Synthesis, Latvian Academy of
Sciences, Riga, 226006, LatviaUSSR
Published online: 23 Sep 2006.
To cite this article: F. Polyak , T. Dorofeeva , R. Sturkovich & Yu. Goldberg (1991) A
Novel Route to N-Alkylated Derivatives of Aziridine-2-Carboxylic Acid. an Alternative
Synthesis of (S,S)-Bz-Azy-Val-OMe, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 21:2, 239-248, DOI:
10.1080/00397919108020818
To link to this article: http://dx.doi.org/10.1080/00397919108020818
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