Analogues of the 5-HT(1A) serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced α1-adrenergic affinity

DOI: 10.1021/jm00112a043

Source and publish data:

Journal of Medicinal Chemistry p. 2633 - 2638 (1991)

Update date:2022-07-29

Topics:

Authors:

Raghupathi

Rydelek-Fitzgerald

Teitler Teitler

Glennon Glennon

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00112a043

1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (NAN-190; 1a) is a putative postsynaptic 5-HT(1A) serotonin antagonist. This high affinity ligand (K(i) = 0.6 nM), although selective for 5-HT(1A) versus other 5-HT receptors, binds with nearly equa

Full text of DOI:10.1021/jm00112a043

Products guided by the article

Product name:2-{4-[4-(2,5-Dimethoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione

Cas No:134390-53-7

R&D Labs maybe for 134390-53-7

Beijing Century Richap Chemistry Co.,Ltd

Contact:+86- 010-64455497

Address:Guannan County, Lianyungang City, Jiangsu Province, China
Shanghai Minstar Chemical Co., Ltd

website:http://www.minstargroup.com

Contact:86-21-18019205509

Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA
Shijiazhuang Frontierchem Co., Ltd.

Contact:+86-311-89271196

Address:4-4-202 No.15 Biandian Street,Shijiazhuang
Shanghai Hanshare Industry Co.,Ltd.

Contact:86 21 20960688

Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
A-Chem Technologies Co.,Ltd.

Contact:+86-512-69561895

Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China

Relevant to this article

Elaboration of peptidomimetics derived from a PADAM approach: Synthesis of polyfunctionalised 2(1H)-pyrazinones via an unexpected aromatisation

Doi:10.1055/s-0030-1260807
(2011)
Redox-Triggered Switchable Synthesis of 3,4-Dihydroquinolin-2(1 H)-one Derivatives via Hydride Transfer/ N-Dealkylation/ N-Acylation

Doi:10.1021/acs.orglett.0c03863
(2021)
Synthesis and herbicidal evaluation of triketone-containing quinazoline-2,4-diones

Doi:10.1021/jf5048089
(2014)
Synthesis of hetarenoindanone based on selenium dioxide-promoted direct intramolecular cyclization

Doi:10.3987/COM-11-12284
(2011)
Reactivity studies of a corrole germanium hydride complex with aldehydes, olefins and alkyl halides

Doi:10.1039/c1cc15076f
(2011)
Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors

Doi:10.1021/jm200870n
(2011)

Article Doi