Analogues of the 5-HT(1A) serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced α1-adrenergic affinity

DOI: 10.1021/jm00112a043

Source and publish data:

Journal of Medicinal Chemistry p. 2633 - 2638 (1991)

Update date:2022-07-29

Topics:

Authors:

Raghupathi

Rydelek-Fitzgerald

Teitler Teitler

Glennon Glennon

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00112a043

1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (NAN-190; 1a) is a putative postsynaptic 5-HT(1A) serotonin antagonist. This high affinity ligand (K(i) = 0.6 nM), although selective for 5-HT(1A) versus other 5-HT receptors, binds with nearly equa

Full text of DOI:10.1021/jm00112a043

Products guided by the article

Product name:2-{4-[4-(2,5-Dimethoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione

Cas No:134390-53-7

R&D Labs maybe for 134390-53-7

Shanghai shibo Chemical Co., Ltd

Contact:+86-021-60753516

Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Changzhou BaoKang Pharmaceutical & Chemical Co., Ltd

Contact:(86) 519-88782201 88784080 88785278

Address:Henglin town, changzhou,Jiangsu
Xinjiang Fufeng Biotechnologies Co., Ltd.

Contact:+86-539-7287111

Address:GANQUANPU INDUSTRIAL PARK, ECONOMIC AND TECHNOLOGICAL DEVELOPMENT AREA (TOUTUNHE DISTRICT) OF URUMQI
Jinan Jiaquan Chemical Co.,Ltd

Contact:+86-531-62318366

Address:Room 502 of Yidonghuayuan No.601 Huaxin Road Licheng District Jinan China
Xi'an North Information Industry Co., Ltd. Weilv Chemical Department

Contact:+86-29-88156413

Address:Jixiang Road 99 Xi'an Shaanxi Province

Relevant to this article

Elaboration of peptidomimetics derived from a PADAM approach: Synthesis of polyfunctionalised 2(1H)-pyrazinones via an unexpected aromatisation

Doi:10.1055/s-0030-1260807
(2011)
Redox-Triggered Switchable Synthesis of 3,4-Dihydroquinolin-2(1 H)-one Derivatives via Hydride Transfer/ N-Dealkylation/ N-Acylation

Doi:10.1021/acs.orglett.0c03863
(2021)
Synthesis and herbicidal evaluation of triketone-containing quinazoline-2,4-diones

Doi:10.1021/jf5048089
(2014)
Synthesis of hetarenoindanone based on selenium dioxide-promoted direct intramolecular cyclization

Doi:10.3987/COM-11-12284
(2011)
Reactivity studies of a corrole germanium hydride complex with aldehydes, olefins and alkyl halides

Doi:10.1039/c1cc15076f
(2011)
Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors

Doi:10.1021/jm200870n
(2011)

Article Doi