Synthesis of L-669,262, a Potent HMG-CoA Reductase Inhibitor

Article abstract of DOI:10.1021/jo00099a030

Synthesis of L-669,262, isosimvastatin-3-one, has been achieved in seven steps from simvastatin (MK-733) and has been shown to be one of the most potent inhibitors of HMG-CoA reductase found to date.The synthesis of the 6-methyl homolog of simvastatin is also described.