Synthesis of L-669,262, a Potent HMG-CoA Reductase Inhibitor

DOI: 10.1021/jo00099a030

Source and publish data:

Journal of Organic Chemistry p. 5983 - 5986 (1994)

Update date:2022-08-04

Topics:: Authors:

Stokker, Gerald E.

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Article abstract of DOI:10.1021/jo00099a030

Synthesis of L-669,262, isosimvastatin-3-one, has been achieved in seven steps from simvastatin (MK-733) and has been shown to be one of the most potent inhibitors of HMG-CoA reductase found to date.The synthesis of the 6-methyl homolog of simvastatin is also described.

Full text of DOI:10.1021/jo00099a030

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Article Doi

Synthesis of L-669,262, a Potent HMG-CoA Reductase Inhibitor

DOI: 10.1021/jo00099a030

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jo00099a030

Full text of DOI:10.1021/jo00099a030

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