Journal of Organic Chemistry p. 5983 - 5986 (1994)
Update date:2022-08-04
Topics:
Stokker, Gerald E.
Synthesis of L-669,262, isosimvastatin-3-one, has been achieved in seven steps from simvastatin (MK-733) and has been shown to be one of the most potent inhibitors of HMG-CoA reductase found to date.The synthesis of the 6-methyl homolog of simvastatin is also described.
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