A synthetic procedure for the preparation of oligonucleotides without using ammonia and its application for the synthesis of oligonucleotides containing O-4-alkyl thymidines

DOI: 10.1016/S0040-4020(01)92195-7

Source and publish data:

Tetrahedron p. 4171 - 4182 (1992)

Update date:2022-08-04

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Authors:

Eritja Eritja

Robles Robles

Avino Avino

Albericio

Pedroso Pedroso

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Article abstract of DOI:10.1016/S0040-4020(01)92195-7

The preparation of 5'-O-dimethoxytrityl (DMT) and p-nitrophenylethyl (NPEOC, NPE) protected nucleosides linked to 4-(2-hydroxyethyl)-3-nitrobenzoic acid derivatives is described. These products attached to controlled-pore glass supports and together with

Full text of DOI:10.1016/S0040-4020(01)92195-7

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Product name:4-(2,3'-(5'-O-4,4'-dimethoxytrityl-thymidyl-2'-deoxyribonucleosidyl)carbonyloxyethyl)-3-nitrobenzoate methyl ester

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