Stereoselective synthesis of trans-2,3-disubstituted 5-amino-4-cyano-2,3-dihydrothiophenes

DOI: 10.1055/s-1991-26445

Source and publish data:

Synthesis p. 277 - 278 (1991)

Update date:2022-07-29

Topics:

Authors:

Shestopalov

Bogomolova

Litvinov

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1991-26445

Interaction of 1-(1-adamantylcarbonylmethyl)pyridinium bromide (1) with arylmethylenecyanothioacetamides 2 proceeds stereoselectively with formation of 2-(1-adamantylcarbonyl)-5-amino-3-aryl-4-cyano-2,3-dihydrothiophenes. Dihydrothiophenes were obtained in a good yield by three-component condensation of pyridinium bromide 1, aldehydes and cyanothioacetamide in presence of triethylamine.

Full text of DOI:10.1055/s-1991-26445

Products guided by the article

Product name:(4R,5R)-5-(Adamantane-1-carbonyl)-2-amino-4-(4-bromo-phenyl)-4,5-dihydro-thiophene-3-carbonitrile

Cas No:134513-91-0

R&D Labs maybe for 134513-91-0

Shanghai Rich Chemicals Co., Ltd

website:http://www.richchemical.com

Contact:+86-21-20255798

Address:Pudong Shanghai,China
Jinan Jianfeng Chemical Co., Ltd

Contact:0086-531-88110457

Address:sales01(-a-t-)pharmachemm{dot}c+o+m
Huzhou City Linghu Xinwang Chemical Co.,Ltd.

Contact:86-572-3948695/3945236

Address:huzhou
Jiangsu Fengshan Group Co., Ltd.

Contact:86-25-86558671

Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
Hangzhou LINGEBA Technology Co., Ltd.

Contact:+0086-571-87389059

Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China

Relevant to this article

Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

Doi:10.1021/acsmedchemlett.5b00402
(2016)
Synthesis of uronic-Noeurostegine - A potent bacterial β-glucuronidase inhibitor

Doi:10.1039/c1ob06038d
(2011)
Reaction of 2-nitro and 3-nitro-2-cyclohexenone acetals: Preparation of useful intermediates

Doi:10.1016/S0040-4020(01)96113-7
(1991)
Dye-Sensitized Photooxidation of 6-Acyl- and 6-Carboalkoxybenzocycloalken-5-ones: Reaction of Singlet Oxygen with Enolic 1,3-Dicarbonyl Compounds

Doi:10.1021/jo00053a056
(1993)
Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461

Doi:10.1016/j.bmcl.2015.05.082
(2015)
A Novel Synthesis of Methylenecyclopropane Spiro-Linked with Cycloalkanes via a Cyclization of Allylic Epoxides and Its Application to a Synthesis of Fused 3-Methylfurans

Doi:10.1246/bcsj.64.1129
(1991)

Article Doi