Stereoselective synthesis of trans-2,3-disubstituted 5-amino-4-cyano-2,3-dihydrothiophenes

DOI: 10.1055/s-1991-26445

Source and publish data:

Synthesis p. 277 - 278 (1991)

Update date:2022-07-29

Topics:

Authors:

Shestopalov

Bogomolova

Litvinov

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1991-26445

Interaction of 1-(1-adamantylcarbonylmethyl)pyridinium bromide (1) with arylmethylenecyanothioacetamides 2 proceeds stereoselectively with formation of 2-(1-adamantylcarbonyl)-5-amino-3-aryl-4-cyano-2,3-dihydrothiophenes. Dihydrothiophenes were obtained in a good yield by three-component condensation of pyridinium bromide 1, aldehydes and cyanothioacetamide in presence of triethylamine.

Full text of DOI:10.1055/s-1991-26445

Products guided by the article

Product name:(4R,5R)-5-(Adamantane-1-carbonyl)-2-amino-4-(4-bromo-phenyl)-4,5-dihydro-thiophene-3-carbonitrile

Cas No:134513-91-0

R&D Labs maybe for 134513-91-0

Springchem New Material Technology Co.,Limited

website:http://www.spring-chem.com

Contact:86-21-62885108

Address:602B, Building 1, No. 641, Tianshan Road
Puyang Huicheng Electronic Material Co., Ltd

website:http://huichengchem.weba.testwebsite.cn/index_en.html

Contact:+86-393-8910800

Address:West Section Shengli Road, Puyang457000, China
Phytomarker Ltd.(expird)

Contact:+86-22-26358246

Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
ORCHID CHEMICAL SUPPLIES LTD

website:http://www.orchid-chem.com

Contact:+86-571-85395792

Address:607, North Zhongshan Road, Hangzhou 310000 China
Hubei anhuang chemical Co.Ltd

Contact:

Address:308# dongwu avenue dongxihu district wuhan city

Relevant to this article

Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication

Doi:10.1021/acsmedchemlett.5b00402
(2016)
Synthesis of uronic-Noeurostegine - A potent bacterial β-glucuronidase inhibitor

Doi:10.1039/c1ob06038d
(2011)
Reaction of 2-nitro and 3-nitro-2-cyclohexenone acetals: Preparation of useful intermediates

Doi:10.1016/S0040-4020(01)96113-7
(1991)
Dye-Sensitized Photooxidation of 6-Acyl- and 6-Carboalkoxybenzocycloalken-5-ones: Reaction of Singlet Oxygen with Enolic 1,3-Dicarbonyl Compounds

Doi:10.1021/jo00053a056
(1993)
Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461

Doi:10.1016/j.bmcl.2015.05.082
(2015)
A Novel Synthesis of Methylenecyclopropane Spiro-Linked with Cycloalkanes via a Cyclization of Allylic Epoxides and Its Application to a Synthesis of Fused 3-Methylfurans

Doi:10.1246/bcsj.64.1129
(1991)

Article Doi