Synthesis of an α-CH2CO2H functionalized tryptophan and its incorporation into an analogue of cholecystokinin

Article abstract of DOI:10.1016/S0040-4020(01)86480-2

The synthesis of an α, α-bisubstituted tryptophan derivative (2) predicted by computer assisted molecular modelling to have close structural and conformational analogy to the endogenous neuropeptide cholecystokinin (CCK) is described. Central to the synth