A new chemoenzymatic enantioselective synthesis of R-(-)-tomoxetine, (R)- and (S)-fluoxetine

DOI: 10.1016/S0040-4039(00)85993-6

Source and publish data:

Tetrahedron Letters p. 1901 - 1904 (1991)

Update date:2022-08-02

Topics:

Authors:

Kumar, Ashok

Ner, Dilip H.

Dike, Suneel Y.

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Article abstract of DOI:10.1016/S0040-4039(00)85993-6

A new chemoenzymatic synthesis of optically pure (R)-Tomoxetine and both the enantiomers of Fluoxetine starting from (S)-ethyl-3-hydroxy-3-phenyl propionate obtained by enzymatic methods, is described.

Full text of DOI:10.1016/S0040-4039(00)85993-6

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