Synthesis of 2-Amino-9-(3'-Azido-2',3'-Dideoxy-Beta-D-Erythro-Pentofuranosyl)-6-Methoxy-9H-Purine (AzddMAP) and AzddGuo

DOI: 10.1016/S0040-4039(00)93545-7

Source and publish data:

Tetrahedron Letters p. 5745 - 5748 (1991)

Update date:2022-08-03

Topics:

Authors:

Almond, Merrick R.

Collins, Jon L.

Reitter, Barbara E.

Rideout, Janet L.

Freeman, G. Andrew

St Clair, Marty H.

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Article abstract of DOI:10.1016/S0040-4039(00)93545-7

A novel synthesis of AzddMAP and AzddGuo is described starting from 1, 2-O-isopropylidene-alpha-D-xylofuranose.The key step in this synthesis involves the replacement of a diphenyl carbamoyl protecting group in the purine 6-position by methanol.

Full text of DOI:10.1016/S0040-4039(00)93545-7

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Product name:Acetic acid (2R,3R,4S,5R)-2-(2-acetylamino-6-diphenylcarbamoyloxy-purin-9-yl)-4-methanesulfonyloxy-5-methoxycarbonyloxymethyl-tetrahydro-furan-3-yl ester

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