ISOLATION AND STRUCTURE DETERMINATION OF (+)-TRIENOMYCIN F. AN ENDGAME SYNTHETIC STRATEGY FOR THE TRIENOMYCIN FAMILY OF ANTITUMOR ANTIBIOTICS

Article abstract of DOI:10.1016/S0040-4039(00)74289-4

A new trienomycin antibiotic, (+)-trienomycin F (4), has been isolated and characterized.The structure was elucidated via spectroscopic comparison with semisynthetic 4 prepared from (+)-trienomycinol (5).The latter sequence implemented an endgame syntheti