An efficient and concise entry to (-)-4,5-dihydroxy-d-threo-l norvaline. Formal synthesis of clavalanine

Article abstract of DOI:10.1016/0040-4039(91)85018-Z

The title amino acid (2) has been synthesized for the first time in a seven-step sequence from D-ribonolactone, in 20% overall yield. Since the N-carbamoyl derivative of (2) in its y-lactone form has been used to prepare clavalanine, a formal total synthe