Bioorganic and Medicinal Chemistry Letters p. 183 - 188 (1998)
Update date:2022-08-03
Topics:
Lages, Adriana S.
Silva, Kelli C. M.
Miranda, Ana L. P.
Fraga, Carlos A. M.
Barreiro, Eliezer J.
Four new aryl-sulfonamide derivatives (3a, 4a, 5a-b), having methylenedioxy group attached to phenyl ring, were prepared from natural safrole and evaluated as anti-inflammatory agents. The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay.
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