AN EFFICIENT PREPARATION OF 3-AZABICYCLOOCT-5-EN-7-ONES FROM PROPARGYL ALCOHOL-COBALT COMPLEXES VIA NICHOLAS REACTION WITH AMIDIC NITROGEN NUCLEOPHILES FOLLOWED BY PAUSON-KHAND CYCLIZATION

Article abstract of DOI:10.1016/S0040-4039(00)71257-3

3-Azabicyclo<3.3.0>oct-5-en-7-ones were efficiently prepared from cobalt-propargyl alcohol complexes and various allyl amides via Nicholas reaction in the presence of BF3*Et2O followed by Pauson-Khand cyclization promoted with trimethylamine N-oxide or SiO2.