New synthesis of (±)-2-piperazinecarboxylic acid

DOI: 10.1016/S0040-4039(00)74356-5

Source and publish data:

Tetrahedron Letters p. 2469 - 2470 (1991)

Update date:2022-09-26

Topics:

Authors:

Merour Merour

Coadou Coadou

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Article abstract of DOI:10.1016/S0040-4039(00)74356-5

(±)-2-Piperazinecarboxylic acid is prepared from N-carbethoxy-4-piperidone by α Schmidt rearrangement followed by bromation of the lactam; then α Favorskii rearrangement on the monobromolactam intermediate afforded the desired product.

Full text of DOI:10.1016/S0040-4039(00)74356-5

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