Synthesis of (+)-ambrisentan via chiral ketone-catalyzed asymmetric epoxidation

Article abstract of DOI:10.1021/jo201927m

The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric epoxi