N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4- dihydrophthalazin-1-yl)-1H-indol-3-yl)acetic acid derivatives

DOI: 10.1016/j.tetlet.2011.08.169

Source and publish data:

Tetrahedron Letters p. 6317 - 6320 (2011)

Update date:2022-08-04

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Authors:

Papaioannou, Nikolaos

Marathias, Vasilios

Wan, Zhao-Kui

Kaila, Neelu

Ali, Zahid

Saiah, Eddine

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Article abstract of DOI:10.1016/j.tetlet.2011.08.169

A convenient synthesis of 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)- 1H-indol-3-yl)acetic acid derivatives is described using a microwave-promoted multi-step S_NAr reaction. The desired products were found to exhibit atropisomerism.

Full text of DOI:10.1016/j.tetlet.2011.08.169

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