Synthesis of 2-substituted benzothiazoles from 2-fluorophenylisothiocyanate

Article abstract of DOI:10.1080/00397919108020829

Treatment of 2-fluorophenylisothiocyanate with a Grignard reagent, followed by base-induced cyclization of the resulting thioamide, provides a convenient method of synthesizing 2-substituted benzothiazoles. Best results are obtained upon isolation and purification of the intermediate thioamide, but a direct one-pot isothiocyanate-to-benzothiazole transformation has also been achieved.

Full text of DOI:10.1080/00397919108020829

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Synthesis of 2-Substituted
Benzothiazoles from 2-
Fluorophenylisothiocyanate
Jeffrey J. Ares a b
a Department of Chemistry , Worcester Polytechnic
Institute , Worcester, Massachusetts, 01609
b The Procter and Gamble Company, Miami Valley
Laboratories , P.O. Box 398707, Cincinnati, OH,
45239-8707
Published online: 23 Sep 2006.
To cite this article: Jeffrey J. Ares (1991) Synthesis of 2-Substituted Benzothiazoles
from 2-Fluorophenylisothiocyanate, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 21:5, 625-633, DOI:
10.1080/00397919108020829
To link to this article: http://dx.doi.org/10.1080/00397919108020829
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