Synthesis and Receptor Binding of Enantiomeric N-Substituted cis-N--2-(1-pyrrolidinyl)cyclohexylamines as High-Affinity ? Receptor Ligands

Article abstract of DOI:10.1021/jm00114a015

N-Alkyl-substituted derivatives of (+)- and (-)-cis-N-<2-(3,4-dichlorophenyl)ethyl>-2-(1-pyrrolidinyl)cyclohexylamine have been synthesized in nine steps in a stereospecific manner starting from cyclohexene oxide.The key step in the reaction sequence invo