Poststatin, a new inhibitor of prolyl endopeptidase IV. The chemical synthesis of poststatin

Article abstract of DOI:10.7164/antibiotics.49.287

Total synthesis of poststatin was achieved by both liquid phase and solid phase methods. In both methods, the (2R,3S)-3-amino-2-hydroxyvaleric acid moiety was incorporated into protected pentapeptides, and was oxidized to (S)-3-amino-2-oxovaleric acid (po