Organic Letters
Letter
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(11) Initially reported as an accidental discovery by S. L. Abidi in
1985 and further developed by the group of S. Z. Zard in the 1990’s, a
controlled nitrosative cleavage of disubstituted isoxazol-5-ones affords
the corresponding internal alkynes. For the pioneering work of Abidi,
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(13) CCDC 1061578 contains the supplementary crystallographic
data for this paper. These data can be obtained free of charge from
(14) The relative stereochemistry of the major diastereoisomer of 4j
is inferred in analogy to 4i, assuming that similar transition states are
involved in both processes.
(15) This strategy has been employed in different contexts by a
number of catalytic protocols. For instance, see: (a) Okamoto, K.;
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D
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