Bioorganic and Medicinal Chemistry Letters p. 7268 - 7272 (2011)
Update date:2022-08-03
Topics:
Erra, Montse
Moreno, Imma
Sanahuja, Jordi
Andres, Miriam
Reinoso, Raquel F.
Lozoya, Estrella
Pizcueta, Pilar
Godessart, Nuria
Castro-Palomino, Julio Cesar
The structure-activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHODH inhibitors which in addition showed good antiproliferative activities on peripheral blood mononuclear cells and good efficacies in vivo in the rat adjuvant-induced-arthritis model.
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Doi:10.1002/ejoc.201100642
(2011)Doi:10.1002/chem.201102096
(2011)Doi:10.1002/psc.1412
(2012)Doi:10.1039/c1ob06413d
(2012)Doi:10.1002/chem.201101411
(2011)Doi:10.1016/j.poly.2011.09.010
(2012)
