Enantioselective deprotonation of 8-oxabicyclo[3.2.1]octan-3-one systems using homochiral lithium amide bases

DOI: 10.1016/S0040-4020(01)80520-2

Source and publish data:

Tetrahedron p. 207 - 218 (1993)

Update date:2022-08-05

Topics: Enantioselectivity Deprotonation Isolation and Characterization

Authors:

Bunn Bunn

Cox Cox

Simpkins

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Article abstract of DOI:10.1016/S0040-4020(01)80520-2

The asymmetric transformation of oxabicyclic ketones 6 and 7 into non-racemic enol silanes 12 (88% ee) and 10 (85% ee), respectively, was achieved using the homochiral lithium amide base 4. Conversion of 10 into a known key intermediate 15 for C-nucleosid

Full text of DOI:10.1016/S0040-4020(01)80520-2

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