1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE. V: SYNTHESIS OF BUILT-IN HYDROXYGUANIDINE TRICYCLES AS POTENTIAL ANTICANCER AGENTS

Article abstract of DOI:10.1016/0040-4039(91)80654-O

Two representative built-in hydroxyguanidine tricycles, 10-N-hydroxy-2,3-dihydroimidazo<1,2-b><1,2,4>benzothiadiazine 5,5-dioxide (1a) and 11-N-hydroxy-2,3-dihydro-4H-pyrimido<1,2-c><1,2,4>benzothiadiazine 6,6-dioxide (1b), were obtained in 78percent and