Preparation of Chiral 3-Unsubstituted β-Lactams from 3-Hydroxy β-Lactams by Using the Alkoxyketene-Imine Cycloaddition Reaction as an Approach to the Azetidinone Ring: A Formal Synthesis of the Carbapenem Antibiotic (+)-PS-5.

DOI: 10.1016/0040-4039(91)80701-7

Source and publish data:

Tetrahedron Letters p. 3105 - 3108 (1991)

Update date:2022-08-04

Topics:

Authors:

Palomo, Claudio

Cossio, Fernando P.

Ontoria, Jesus M.

Odriozola, Jose M.

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Article abstract of DOI:10.1016/0040-4039(91)80701-7

Formation of chiral 3-hydroxy β-lactams from the alkoxyketene-imine cycloaddition reaction followed by deoxygenation under Barton's conditions provided a simple route to optically active 3-unsubstituted β-lactams.

Full text of DOI:10.1016/0040-4039(91)80701-7

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