Facile synthesis of 4-N-phosphonomethyl-2,4-diamino-butyrates as inhibitors of glutamine synthetase

Article abstract of DOI:10.1016/0040-4039(91)85065-D

An effective synthesis of N-substituted 2,4-diaminobutyric acids is described involving reaction of amines with methyl 4-bromo-2-phthalimidobutyrate, followed by hydrolysis. This approach was applied to the synthesis of 4-N-phosphonomethyl-2,4-diaminobuty