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Structure-Activity Relationships of a Series of 2-Amino-4-thiazole-Containing Renin Inhibitors

DOI: 10.1021/jm00092a006

Source and publish data:

Journal of Medicinal Chemistry p. 2562 - 2572 (1992)

Update date:2022-08-04

Topics:

Authors:

Patt, William C.Patt, William C.

Hamilton, Harriet W.Hamilton, Harriet W.

Taylor, Michael D.Taylor, Michael D.

Ryan, Michael J.Ryan, Michael J.

Taylor, David G.Taylor, David G.

et al.et al.

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Article abstract of DOI:10.1021/jm00092a006

A series of renin inhibitors was synthesized that contained a 2-amino-4-thiazolyl moiety at the P2 position.These derivatives are potent inhibitors of monkey renin in vitro and are selective in that they only weakly inhibit the closely related

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Full text of DOI:10.1021/jm00092a006

Products guided by the article

Product name:4-((S)-1-{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-ethylcarbamoyl}-2-phenyl-ethylsulfamoyl)-piperazine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Cas No:135704-09-5

135704-09-5

R&D Labs maybe for 135704-09-5

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