Structure-Activity Relationships of a Series of 2-Amino-4-thiazole-Containing Renin Inhibitors

Article abstract of DOI:10.1021/jm00092a006

A series of renin inhibitors was synthesized that contained a 2-amino-4-thiazolyl moiety at the P₂ position.These derivatives are potent inhibitors of monkey renin in vitro and are selective in that they only weakly inhibit the closely related