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arrangement of the inhibitor which consequently reduces their
binding affinity.
Further optimizations as well as in-depth structural and biolog-
ical studies of the selected PCU derived-peptide/peptoid based pro-
tease inhibitors are the subject of ongoing investigations.
Acknowledgments
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This research was supported by NRF (SA) TG (GUN: 66319), KP
(GUN: 69728), HGK and PIA (SA-Sweden bilateral grant), Aspen
Pharmacare and University of KwaZulu-Natal for financial support.
Y.S would like to thank the Carnegie Corporation of New York and
the NRF for financial support. The authors thank Prof. Jürgen
Schleucher (Umeå University, Sweden) and Mr. Dilip Jagjivan
(UKZN, South Africa) for their assistance with the NMR
experiments.
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Appendix A. Supplementary material
Supplementary data associated with this article can be found, in
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