A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds

Article abstract of DOI:10.1021/jo00020a002

Treatment of N-protected 4-iodoimidazoles 1-3 in CH2Cl2 solution with an etheral solution of ethylmagnesium bromide generates the corresponding imidazol-4-yl anions, which react with carbonyl compounds to give carbinols 4-14 in 60-83percent yield.