A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds

DOI: 10.1021/jo00020a002

Source and publish data:

Journal of Organic Chemistry p. 5739 - 5740 (1991)

Update date:2022-07-30

Topics:

Authors:

Turner, Richard M.

Lindell, Stephen D.

Ley, Steven V.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00020a002

Treatment of N-protected 4-iodoimidazoles 1-3 in CH2Cl2 solution with an etheral solution of ethylmagnesium bromide generates the corresponding imidazol-4-yl anions, which react with carbonyl compounds to give carbinols 4-14 in 60-83percent yield.

Full text of DOI:10.1021/jo00020a002

Products guided by the article

Product name:4-(Hydroxy-phenyl-methyl)-imidazole-1-sulfonic acid dimethylamide

Cas No:135799-03-0

R&D Labs maybe for 135799-03-0

WD Silicone Co., Ltd

Contact:+86-27-87204219, +86-27-87215023

Address:2402, HuiGu Space-time Building, 8 Forest Road, East Lake Hi-Tech Development Zone
Shantou Baokang Pharmaceutical Co., Ltd.

Contact:+86-754-88873487

Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
Tomo Pharma Chem Co., Limited

Contact:+86-158-05817090

Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Jiangsu Haian Petro chemical Plant

Contact:+86-513-88902723

Address:99, Changjiang West Road, Haian County, Jiangsu
Xinji City Taida Sinopec Co., Ltd.

Contact:0086-311-85341278

Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China

Relevant to this article

A traceless vascular-targeting antibody-drug conjugate for cancer therapy

Doi:10.1002/anie.201106527
(2012)
A functionalized spiro[chlorin-porphyrin]-type 'dimer' dizinc complex from rapid [4+2] self-cycloaddition of a conjugated [β,β′- bis(methylene)porphyrinato]zinc

Doi:10.1002/hlca.201100385
(2012)
Analogues of substance P containing an α-hydroxy, β-amino acid: Synthesis and biological activity

Doi:10.1016/0223-5234(91)90104-U
(1991)
Doi:10.1002/hlca.19660490420
(1966)
Efficient synthesis of carbazoles via PtCl₂-catalyzed RT cyclization of 1-(indol-2-yl)-2,3-allenols: Scope and mechanism

Doi:10.1039/c1ob06474f
(2012)
Intramolecular domino electrophilic and thermal cyclization of peri-ethynylene naphthalene oligomers

Doi:10.1002/chem.201102506
(2011)

Article Doi