Macrocyclic Renin Inhibitors: Synthesis of A Subnanomolar, Orally Active Cysteine Derived Inhibitor

DOI: 10.1016/S0040-4039(00)61590-3

Source and publish data:

Tetrahedron Letters p. 7035 - 7038 (1993)

Update date:2022-09-26

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Authors:

Yang, Lihu

Weber, Ann E.

Greenlee, William J.

Patchett, Arthur A.

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Article abstract of DOI:10.1016/S0040-4039(00)61590-3

A class of novel thioether linked macrocyclic renin inhibitors was synthesized.A key element of the synthesis is the use of boroxazolidone for the simultaneous protection of the amino and carboxyl groups in L-cysteine.

Full text of DOI:10.1016/S0040-4039(00)61590-3

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