Asymmetric synthesis X III: The stereocontrolled synthesis of (R)-α-amino acids via a double chiral induction

Article abstract of DOI:10.1080/00397919108019799

The stereocontrolled synthesis of (R)-α-amino acids via a double chiral induction in alkylation of the ketimine derived from (+)-camphor and (+)-methyl glycinate which is a chiral match pair has been studied. (R)-α-amino acids with high optical purity 80-90% are obtained after hydrolysis of the alkylated products. We find that the chiral match which is the synergistic effect in a double chiral induction is very important to obtain the higher diastereoselectivity for the stereocontrolled synthesis.

Full text of DOI:10.1080/00397919108019799

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Synthetic Communications: An
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Organic Chemistry
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Asymmetric Synthesis XIII: The
Stereocontrolled Synthesis
of (R)—α—Amino Acids via a
Double Chiral Induction
Jiang Yao Zhong a , Liu Guilan a , Zhou Changyou a ,
Piao Hauri a , Wu Lanjun a & Mi Aiqiao a
a Chengdu Institute of Organic Chemistry , Academia
Sinica , Chengdu, 610015, P. R. China
Published online: 23 Sep 2006.
To cite this article: Jiang Yao Zhong , Liu Guilan , Zhou Changyou , Piao Hauri , Wu
Lanjun & Mi Aiqiao (1991) Asymmetric Synthesis XIII: The Stereocontrolled Synthesis
of (R)—α—Amino Acids via a Double Chiral Induction, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
21:8-9, 1087-1090, DOI: 10.1080/00397919108019799
To link to this article: http://dx.doi.org/10.1080/00397919108019799
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