Synthesis and Biological activity of new HMG-CoA reductase inhibitors. 3.1,2 lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids

DOI: 10.1021/jm00114a004

Source and publish data:

Journal of Medicinal Chemistry p. 2962 - 2983 (1991)

Update date:2022-08-03

Topics:

Authors:

Jendralla

Granzer Granzer

V Kerekjarto

Krause Krause

Schacht Schacht

Baader Baader

Bartmann

Beck Beck

Bergmann

Kessler Kessler

Wess Wess

Chen Chen

Granata Granata

Herchen Herchen

Kleine Kleine

Schussler

Wagner Wagner

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Article abstract of DOI:10.1021/jm00114a004

A group of 43 optically active sodium carboxylates (11a-qq and the corresponding lactones 4 were prepared from respective phenols 8 according to Schemes I-III. Phenols 8 were synthesized from commercially available compounds according to Schemes IV-IX. A

Full text of DOI:10.1021/jm00114a004

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Product name:3-(cyclohexylmethyl)-5-isopropyl-4-nitrobiphenyl

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