FEATURES OF SYNTHESIS AND STRUCTURE
121
7. DE Patent no. 4425648, 1996, C. A., 1996, vol. 124,
2.7); 16.13 t.d.d (1F, J = 21.3, 19.1, 8.6); 25.33 m
(1F); 26.09 m (1F); (B): 7.27 t.t (1F , J = 19.8, 2.7);
10.86 m (1F); 23.69 m (1F); 24.85 t.d.d (1F, J = 19.9,
13.3, 6.8). Found, %: C 49.64, H 3.17; F 28.67.
C11H8F4O3. Calculated, %: C 50.01, H 3.05; F 28.77.
Retention time 14.91 min. Mass spectrum, m/z (I, %):
264 (11) [M]+•, 218 (9) [M – EtOH]+•, 177 (100)
[HC6F4C (O)]+•, 149 (15) [HC6F4]+•.
289570.
8. Asahina, Y., Takei, M., Kimura, T., and Fukuda, Y.,
J. Med. Chem., 2008, vol. 51, no. 11, p. 3238.
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and Vorozhtsov, N.N., Jr., Zh. Obshch. Khim., 1967,
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In the reaction of III with 20% aqueous solution of
sulfuric acid the product I contained 2% of 2,3,4,5-
tetrafluorophenyl methyl ketone IV (determined by
GC-MS). Retention time: 8.20 min. Mass spectrum,
m/z (I, %): 192 (15) [M]+•, 177 (100) [HC6F4C(O)]+•,
149 (15) [HC6F4]+•, 43 (7) [CH3C(O)]+•.
11. Prudchenko, A.T., Barkhash, V.A., and Vorozh-
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ACKNOWLEDGMENTS
14. Chu, D.T.W., Fernandes, P.B., Claiborn, A.K.,
Gracey, E.H., and Pernet, A.G., J. Med. Chem., 1986,
vol. 29, no. 11, p. 2363.
This work was performed along the State Contract
no. 02.522.12.2011.
15. Chu, D.T.W., Fernandes, P.B., Maleczka, R.E., Jr.,
Nordeen, C.W., and Pernet, A.G., J. Med. Chem., 1987,
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