Stereoselective Synthesis of Lignans of Three Structural Types from a Common Intermediate, Enantioselective Synthesis of (+)-Yangambin

Article abstract of DOI:10.1002/ejoc.201402584

Enantioselective total synthesis of (+)-yangambin was achieved. The key transformation is one-pot conjugate addition/aldol reaction that involves an enantioenriched benzyl tert-butyl sulfoxide, an enone, and gaseous formaldehyde to construct the bis(pheny