Preparation of acyclic N-acyl-N,O-acetals by decarboxylation of N-protected α-amino acids and studies of asymmetric amidoalkylation with trimethylsilyl cyanide

Article abstract of DOI:10.1080/00397919108021290

Oxidative decarboxylation of N-acyl-α-amino acids with lead tetraacetate followed by treatment with methanol provides a facile method for preparation of acyclic N-acyl-N,O-acetals, which can be used in asymmetric α-amidoalkylation reactions using trimethylsilyl cyanide as nucleophile.

Full text of DOI:10.1080/00397919108021290

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Preparation of Acyclic N-Acyl-
N,O-acetals by Decarboxylation
of N-Protected α-Amino Acids
and Studies of Asymmetric
Amidoalkylation with
Trimethylsilyl Cyanide
Kenn E. Harding a , Lee T. Liu a , David G. Farrar a
M. Todd Coleman a & Susan K. Tansey a
,
a Department of Chemistry , Texas A&M University ,
College Station, TX, 77843
Published online: 23 Sep 2006.
To cite this article: Kenn E. Harding , Lee T. Liu , David G. Farrar , M. Todd
Coleman & Susan K. Tansey (1991) Preparation of Acyclic N-Acyl-N,O-acetals
by Decarboxylation of N-Protected α-Amino Acids and Studies of Asymmetric
Amidoalkylation with Trimethylsilyl Cyanide, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry,
21:12-13, 1409-1417, DOI: 10.1080/00397919108021290
To link to this article: http://dx.doi.org/10.1080/00397919108021290
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