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Non-bonded interactions were treated with an atom-based cutoff
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Acknowledgments
T. M. Beale was funded by the Cambridge Cancer Research UK
PhD Training Programme for Medicinal Chemistry. P. J. Bond
thanks Unilever for funding. The computational work benefited
from use of the Darwin Supercomputer of the University of Cam-
cam.ac.uk/) provided by Dell Inc. using Strategic Research, Infra-
structure Funding from the Higher Education Funding Council for
England. The authors would like to thank Richard Farndale for
the xCELLigence facilities at the Department of Biochemistry, Uni-
versity of Cambridge, and Andreas Bender at the Unilever Centre
for Molecular Informatics, University of Cambridge for helpful dis-
cussions about the computational studies. S. V. Ley acknowledges
support from the BP Endowment.
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immediately after characterisation.
Supplementary data
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32. Compounds stable in DMSO solution for up to 18 months, shown by LC-MS
analysis.
Supplementary data associated with this article can be found, in
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