Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Article abstract of DOI:10.1016/j.bmc.2011.10.080

Benzodiazepines are psychoactive drugs with anxiolytic, sedative, skeletal muscle relaxant and amnestic properties. Recently triazolo-benzodiazepines have been also described as potent and highly selective protein interaction inhibitors of bromodomain and