An asymmetric synthesis of (-)-carbovir

DOI: 10.1016/0957-4166(94)80072-3

Source and publish data:

Tetrahedron Asymmetry p. 1649 - 1652 (1994)

Update date:2022-08-03

Topics:

Authors:

Asami Asami

Takahashi

Inoue Inoue

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0957-4166(94)80072-3

Enantioselective deprotonation of trans-4-t-butyldimethylsiloxymetyl-1,2-epoxycyclopentane (trans-4) by a chiral lithium amide, lithium (S)-2-(pyrrolidin-1-ylmethyl)pyrrolidide (1), afforded (1S,4S)-trans-4-t-butyldimethylsiloxymethyl-2-cyclopenten-1-ol (trans-7) in 83% ee. Alcohol trans-7 was easily transformed to (-)-carbovir, an anti-HIV carbocyclic nucleoside.

Full text of DOI:10.1016/0957-4166(94)80072-3

Products guided by the article

Product name:(1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-Cyclopentene-1- methanol

Cas No:136522-33-3

R&D Labs maybe for 136522-33-3

Chongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.

Contact:86-023-65268721

Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
Zhejiang Kangfeng Chemical Co.,LTD.

Contact:+86-579-86709687

Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
Springchem New Material Technology Co.,Limited

website:http://www.spring-chem.com

Contact:86-21-62885108

Address:602B, Building 1, No. 641, Tianshan Road
Suzhou Time-chem Technologies Co., Ltd.

Contact:0512-63983931/68086856

Address:No. 1326 of Binhe Road, New District, Suzhou, Jiangsu, P. R. China
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China

Relevant to this article

7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation

Doi:10.1016/j.bmc.2012.01.020
(2012)
Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors

Doi:10.1016/j.bmcl.2012.01.046
(2012)
Activity of Acyclic 6-(Phenylselenenyl)pyrimidine Nucleosides against Human Immunodeficiency Viruses in Primary Lymphocytes

Doi:10.1021/jm00115a022
(1991)
Stereoselective intramolecular cyclization to 4-(hydroxymethyl)-3-(1H- indolyl)oxazolidin-2-ones

Doi:10.1002/chir.22003
(2012)
Synthesis of heterocyclic N-(β-d-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase

Doi:10.1016/j.carres.2012.01.020
(2012)
Synthesis and spectroscopic investigations of alkylaluminum alkoxides derived from optically active alcohols. The first structural identification of an optically active organoaluminum alkoxide

Doi:10.1021/om00037a039
(1992)

Article Doi