Activity of Acyclic 6-(Phenylselenenyl)pyrimidine Nucleosides against Human Immunodeficiency Viruses in Primary Lymphocytes

Article abstract of DOI:10.1021/jm00115a022

Several 6-phenylselenenyl-substituted acyclouridine derivatives were prepared for evaluation as antiviral agents.Lithiation of the tert-butyldimethylsilyl-protected acyclonucleosides 4a-f with lithium diisopropylamide at -78 deg C, followed by reaction wi