Bioorganic and Medicinal Chemistry Letters p. 4979 - 4984 (2013)
Update date:2022-07-31
Topics:
Washburn, David G.
Holt, Dennis A.
Dodson, Jason
McAtee, Jeff J.
Terrell, Lamont R.
Barton, Linda
Manns, Sharada
Waszkiewicz, Anna
Pritchard, Christina
Gillie, Dan J.
Morrow, Dwight M.
Davenport, Elizabeth A.
Lozinskaya, Irina M.
Guss, Jeffrey
Basilla, Jonathan B.
Negron, Lorena Kallal
Klein, Michael
Willette, Robert N.
Fries, Rusty E.
Jensen, Timothy C.
Xu, Xiaoping
Schnackenberg, Christine G.
Marino Jr., Joseph P.
Lead optimization of piperidine amide HTS hits, based on an anilino-thiazole core, led to the identification of analogs which displayed low nanomolar blocking activity at the canonical transient receptor channels 3 and 6 (TRPC3 & 6) based on FLIPR (carbac
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