Synthesis of Pyrrolidin-1-yl Analogues of Pyrimidine Dideoxynucleosides

Article abstract of DOI:10.1016/S0040-4039(00)79398-1

The synthesis is described of the first members of a new class of nucleoside analogues in which the tetrahydrofuran ring is replaced by a pyrrolidine ring linked to the base through an N-N bond: the pyrrolidinyl analogues of 2',3'-dideoxycytidine (10), uridine (8), and thymidine (9) were prepared via construction of the base on a 1-aminopyrrolidine (15).