Synthesis of Pyrrolidin-1-yl Analogues of Pyrimidine Dideoxynucleosides

DOI: 10.1016/S0040-4039(00)79398-1

Source and publish data:

Tetrahedron Letters p. 3863 - 3866 (1991)

Update date:2022-08-05

Topics:

Authors:

Harnden, Michael R.

Jarvest, Richard L.

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Article abstract of DOI:10.1016/S0040-4039(00)79398-1

The synthesis is described of the first members of a new class of nucleoside analogues in which the tetrahydrofuran ring is replaced by a pyrrolidine ring linked to the base through an N-N bond: the pyrrolidinyl analogues of 2',3'-dideoxycytidine (10), uridine (8), and thymidine (9) were prepared via construction of the base on a 1-aminopyrrolidine (15).

Full text of DOI:10.1016/S0040-4039(00)79398-1

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