Catalytic Asymmetric Aldol Reaction of the Silyl Enol Ether of Acetic Acid Thioester with Aldehydes Using Chiral Tin(II) Lewis Acid

Article abstract of DOI:10.1016/S0957-4166(00)86116-9

Catalytic asymmetric aldol reaction of the silyl enol ether derived from S-ethyl ethanethioate with achiral aldehydes is carried our by using chiral diamine-coordinated tin(II) triflate to afford the corresponding aldol-type adducts, α-unsubstituted β-hydroxy thioesters, in good yields with high ees.