Novel 2-substituted tetrahydro-3H-benz[e]indolamines: Highly potent and selective agonists acting at the 5-HT(1A) receptor as possible anxiolytics and antidepressants

DOI: 10.1021/jm00067a003

Source and publish data:

Journal of Medicinal Chemistry p. 2066 - 2074 (1993)

Update date:2022-07-29

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Authors:

Romero Romero

Leiby Leiby

McCall McCall

Piercey Piercey

Smith Smith

Han Han

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Article abstract of DOI:10.1021/jm00067a003

The synthesis of (+)-(R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro- 3H-benz[e]indole [(R)-14, U92016A], a potent 5-HT(1A) agonist, and related analogs is described. In vitro binding studies show that the (R)-enantiomers of this series possess the hi

Full text of DOI:10.1021/jm00067a003

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