Novel 2-substituted tetrahydro-3H-benz[e]indolamines: Highly potent and selective agonists acting at the 5-HT(1A) receptor as possible anxiolytics and antidepressants

DOI: 10.1021/jm00067a003

Source and publish data:

Journal of Medicinal Chemistry p. 2066 - 2074 (1993)

Update date:2022-07-29

Topics:

Authors:

Romero Romero

Leiby Leiby

McCall McCall

Piercey Piercey

Smith Smith

Han Han

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00067a003

The synthesis of (+)-(R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro- 3H-benz[e]indole [(R)-14, U92016A], a potent 5-HT(1A) agonist, and related analogs is described. In vitro binding studies show that the (R)-enantiomers of this series possess the hi

Full text of DOI:10.1021/jm00067a003

Products guided by the article

Product name:(+)-(2R)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin

Cas No:136924-89-5

R&D Labs maybe for 136924-89-5

Daqing E-shine Chemical Co.,LTD

Contact:0086-024-31285112

Address:Hongweiyuan area, Ranghulu district
QINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.

Contact:+86 532 80861829

Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Shenyang Xinyihan Chemical Technology Co., Ltd.

Contact:+86-18525026267

Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073

Relevant to this article

Addition of aluminum and gallium species to aromatic and alkyl-substituted 1,4-diaza-1,3-butadiene ligands

Doi:10.1021/ic202583w
(2012)
2,2′-biphospholes: Building blocks for tuning the HOMO-LUMO gap of π-systems using covalent bonding and metal coordination

Doi:10.1002/anie.201105924
(2012)
Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5

Doi:10.1039/c2ob06801j
(2012)
Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis

Doi:10.1021/ja212188r
(2012)
Synthesis of (±)-7-hydroxylycopodine

Doi:10.1021/jo300353t
(2012)
Synthesis of podophyllotoxin derivatives by means of tributyltin hydride- or palladium-mediated cyclization of α-benzylidene-β-(o-bromobenzyl)-γ-lactones

Doi:10.1016/S0040-4020(01)85735-5
(1993)

Article Doi