Novel 2-substituted tetrahydro-3H-benz[e]indolamines: Highly potent and selective agonists acting at the 5-HT(1A) receptor as possible anxiolytics and antidepressants

DOI: 10.1021/jm00067a003

Source and publish data:

Journal of Medicinal Chemistry p. 2066 - 2074 (1993)

Update date:2022-07-29

Topics:

Authors:

Romero Romero

Leiby Leiby

McCall McCall

Piercey Piercey

Smith Smith

Han Han

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00067a003

The synthesis of (+)-(R)-2-cyano-N,N-dipropyl-8-amino-6,7,8,9-tetrahydro- 3H-benz[e]indole [(R)-14, U92016A], a potent 5-HT(1A) agonist, and related analogs is described. In vitro binding studies show that the (R)-enantiomers of this series possess the hi

Full text of DOI:10.1021/jm00067a003

Products guided by the article

Product name:(+)-(2R)-8-bromo-N-<(S)-α-methylbenzyl>-2-aminotetralin

Cas No:136924-89-5

R&D Labs maybe for 136924-89-5

Dalian Synco Chemical Co., Ltd.

Contact:+86-411-83635150

Address:Rm 1004, 24, Tangshan Street, Dalian
Ceresking Ecology & Technology co.,ltd

Contact:86 22 66218397

Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
Beijing Huikang Boyuan Chemical Tech Co.,LTD

Contact:+86-10-68862197

Address:No.7 Haiying Road,Science City,Fengtai District,Beijing,China
Wuxi Zuping Food Science And Technology Co.,LTD.

Contact:+86-510-87210822

Address:Guanlin town
FOSHAN NANHAI ZHONGNAN PHARMACEUTICAL FACTORY

Contact:0086-0757-85609331

Address:XIAHENGTIAN INDUSTRIAL ZONE,SHAYONG VILLAGE,LISHUI TOWN

Relevant to this article

Addition of aluminum and gallium species to aromatic and alkyl-substituted 1,4-diaza-1,3-butadiene ligands

Doi:10.1021/ic202583w
(2012)
2,2′-biphospholes: Building blocks for tuning the HOMO-LUMO gap of π-systems using covalent bonding and metal coordination

Doi:10.1002/anie.201105924
(2012)
Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5

Doi:10.1039/c2ob06801j
(2012)
Enhanced epimerization of glycosylated amino acids during solid-phase peptide synthesis

Doi:10.1021/ja212188r
(2012)
Synthesis of (±)-7-hydroxylycopodine

Doi:10.1021/jo300353t
(2012)
Synthesis of podophyllotoxin derivatives by means of tributyltin hydride- or palladium-mediated cyclization of α-benzylidene-β-(o-bromobenzyl)-γ-lactones

Doi:10.1016/S0040-4020(01)85735-5
(1993)

Article Doi