Synthesis of Borinic Acids and Borinate Adducts Using Diisopropylaminoborane

Article abstract of DOI:10.1021/acs.orglett.5b01620

In situ formation of aryl Grignard under Barbier condition and diisopropylaminoborane as boron source allows a complete control of the addition onto the boron electrophile. Analytically pure borinic acid derivatives were produced at the gram scale without column chromatography and isolated as borinates adducts, with ethanolamine or 8-hydroxyquinoline, after workup.